Ef fect and risk of applying clopi dogrel before elective coronary artery bypass grafting in left main dsi ease
Abstract：Objective To evaluate the safety and effect of applying LMWH ( low molecular weight heparin ) with clopidogrel before elective off-pump coronary artery bypass grafting in left main disease .Methods Retrospective analysis of the 228 patients of left main coronary stenosis cases undertaking elective off-pump coronary bypass grafting .All patients were divided into clopidogrel group ( combined with LMWH ) and pure LMWH group ( applying LMWH only ) .Compare the adverse cardiovascular events ( death,unstable angina pectoris ,acute myocardial infarction ) ,and the post operation hemorrhage in both groups.Results In clopidogrel group,the occurrence rate of adverse cardiovascular events was remarkably lower ,while the postoperative bleeding amount and transfusion amount were a little more than those in LMWH group .There were no obvious differences on intra-aortic balloon pump using ,gastrointestinal bleeding ,cerebral hemorrhage ,thoracotomy hemostasis rate ,the using of positive inotropic drug and the staying time in ICU .Conclusion Compared with merely applying LMWH ,combined applying clopidogrel with LMWH 5 days before elective off-pump coronary bypass grafting can relatively reduce preoperative adverse cardiovascular events in patients of left main coronary stenosis and do not increase the serious bleeding complication .
Keywords：coronary artery bypass graftingclopidogrelLeft main coronary artery stenosis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1445-1448 )