Expression and clinical significance of serum Lipocalin-2 and MMP-9 before and after operation in patients with lung cancer

MA Xiaogang; YANG Xiaoguang; ZHAO Zheng

doi:10.3969/j.issn.1002-7386.2014.09.002

Abstract：Obje ctive To investigate the expression and clinical significance of Lipocalin -2 and MMP-9 before and after operation in patients with lung cancer .Methods The serum levels of Lipocalin-2 and MMP-9 before and after operation were detected by ELISA in 60 patients with lung cancer and 50 healthy subjects.The correlation between the expressions and clinical pathological characteristics was analyzed .Results The serum levels of Lipocalin-2 and MMP-9 in patients with lung cancer were significantly higher than those of healthy subjects ( P <0.05).The expression levels of Lipocalin -2 and MMP-9 were closely correlated to clinical staging and lymph node metastasis ( P <0.05),and the expression levels of Lipocalin-2 were positively related to those of MMP-9 ( r =7.217, P <0.05).The total effective rate of operation was 80.0%.The serum levels of Lipocalin-2 and MMP-9 were significantly decreased after operation ,as compared with those before operation ( P <0.05).There were significant differences in the serum levels of Lipocalin -2,MMP-9 betweem the patients with relapse and the patients without relapse ( P <0.05).C onclusion The overexpression of Lipocalin-2 and MMP-9 is closely related with invasion and metastasis process of lung cancer ,which may play an important role in carcinogenesis ,invasion and metastasis of lung cancer.After operation,the Lipocalin-2 and MMP-9 levels are significantly decreased,and the detection of serum levels of Lipocalin-2 and MMP-9 may be regarded as reliable indexes for evaluating operation efficiency and patient 's prognosis.