Correlation between macroangiopathy due to type 2 diabetes mellitus and Hcy, CysC, hs-CRP
HUANG Qian
LI Yuanyuan
Abstract：Objective To investigate the relationship between homocysteine ( Hcy ) , Cystatin C ( CysC ) , high sensitive C-reactive protein ( hs-CRP) and macroangiopathy due to type 2 diabetes mellitus .Methods Ninety-four patients with type 2 diabetes mellitus were enrolled into Department of Endocrinology of our hospital from April 2012 to April 2013 ,in which 49 patients were complicated by macroangiopathy ( lesion group ) , however , the other 45 patients without macroangiopathy were regarded as no complication group ,besides,46 healthy subjects were enrolled as control group .The venousblood specimens of all the subjects were taken out to be detected for the levels of Hcy ,CysC,hs-CRP,and the results were analyzed and compared among the three groups .Results The levels of Hcy, CysC, hs-CRP in lesion group were significantly high than those in the other two groups ( P <0.01);The levels of Hcy,CysC,hs-CRP in no complication group were significantly high than those in control group ( P <0.05).Logistic regression analysis showed that Hcy ,CysC,hs-CRP were the risk factors to induce macroangiopathy in patients with type 2 diabetes mellitus .Conclusion The levels of Hcy , CysC,hs-CRP are correlated to macroangiopathy in patients with type 2 diabetes mellitus ,which has an important clinical value in predicting macrovascular pathological changes ,meanwhile ,which can be regarded as an new therapeutic target .
Keywords：homocysteinecystatin Chigh sensitivity C-reactive proteintype 2 diabetesmacroangiopathy
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1142-1144 )