Relationship between inflammation factors and diabetic nephropathy in elderly patients
Abstract：Objective To explore the relationship between inflammation factors and diabetic nephropathy in elderly patients .Methods A total of 96 elderly patients with type 2 diabetes mellitus were enrolled in the study .All the patients were divided into three groups according to urinary albumin excretion rate: normal proteinuria group ( UAER <20μg/min ) , microalbuminuria group ( UAER20-200μg/min ) and clinical proteinuria group ( UAER >200μg/min ) .The fasting venous blood specimens of all the patients were taken out , then the serum levels of tumor necrosis factor-α( TNF-α) , interleukin-6 ( IL-6 ) were detected by radio-immunity assay and the serum levels of C-reactive protein ( CRP ) were detected by turbidimetry.Results There were significant differences in the serum levels of TNF-α,IL-6,CRP among the three groups .The serum levels of TNF-α,IL-6,CRP in microalbuminuria group and clinical proteinuria group were significantly higher than those in normal proteinuria group ( P <0.05),moreover,which increased with the aggravation of diabetic nephropathy degree . Conclusion Inflammation factors may be involved in the pathogenesis and development of diabetic nephropathy , and the detection of these inflammation factors is helpful for diagnosis and treatment of diabetic nephropathy in elderly patients .
Keywords：diabetic nephropathythe elderlyinflammation factorsserum tumor necrosis factor-αinterleukin-6C-reactive protein
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1135-1137 )