Changes and clinical significance of serum levels of visfatin,homocysteine and high-sensitivity C reaction protein in patients with type 2 diabetic nephropathy

doi:10.3969/j.issn.1002-7386.2014.08.001

Abstract：Objective To detect the serum levels of visfatin , homocysteine ( Hcy ) and high-sensitivity C reaction protein ( hsCRP ) in patients with type 2 diabetic nephropathy , and to explore their role and clinical significance in pathogenesis and progress of type 2 diabetic nephropathy ( DN ) .Methods A total of 103 patients with type 2 diabetes mellitus were divided into three groups according to the urinary albumin excretion rate ( UAER ): normal albuminuria group ( UAER<20μg/min, n =37 ) , micro-albuminuria group ( UAER 20 ~200μg/min, n =35 ) and macro-albuminuria group ( UAER>200μg/min, n =31 ) ,with 32 healthy subjects as controls .The serum levels of visfatin and Hcy were detected by enzyme linked immunosorbent assay (ELISA) and hsCRP levels were measured by immuno-turbidimetry.Furthermore,fasting plasma glucose ( FPG),HbA1c,fasting insulin (FINS),insulin resistance index (HOMA-IR),blood urea nitrogen (BUN), serum creatinine ( SCr) ,and glomerular filtration rate ( GFR) levels as well as UAER were detected and compared .Results The serum levels of visfatin ,Hcy and hsCRP in diabetic patients were significantly higher than those in control group ( P <0.01).The serum levels of visfatin,Hcy and hsCRP were positively correlated with those of FPG ,HbA1c,HOMA-IR,BUN,Scr and UAER ( P <0.01),however,which were negatively correlated to those of GFR (P<0.01).Furthermore the serum levels of visfatin,Hcy,hsCRP were positively correlated each other .Conclusion The visfatin,Hcy and hsCRP may play an important role in the pathogenesis and development of DN ,and the action mode may be insulin resistance and inflammatory response ,so combined detection may be useful for evaluating early DN .