Expressions and significan ce of c-fos and c-myc protein in skin squamous cell carcinoma
Abstract：Objective To investigate the changes of expression levels of c -fos,c-myc during pathogenesis and development of skin cell squamous carcinoma .Methods The expression levels of c-fos, c-myc were detected by immunohistochemistry in 79 cases of skin squamous cell carcinoma , and the results were compared with those in normal tissues.Results The c-fos and c-myc were not expressed in normal skin ,however,which were expressed in skin squamous cell carcinoma,the positive rates of c-fos and c-myc were 70.9% and 78.5%,respectively.The expression levels of c-fos and c-myc were closely correlated to the differentiation degree of tumor tissue ( P <0.05 ) .The higher differentiation degree of tumor tissue, the higher expression levels of c-fos, however, the higher differentiation degree of tumor tissue , the lower expressionlevels of c-myc.Conclusion The detection of expression levels of c-fos and c-myc can evaluate differentiation degree of skin squamous cell carcinoma and clinical prognosis .
Keywords：oncogene protein c-fosoncogene protein c-myccarcinoma of squamous cellskin neoplasms
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 822-824 )