Correlation between apparent diffusion coefficient and bone mineral density measured by quantitative computed tomography in human lumbar spine
Abstract：Objective To investigate the correlation between apparent diffusion coefficient ( ADC ) detected by magnetic resonance ( MR) diffusion weighted imaging ( DWI ) and bone mineral density ( BMD ) measured by quantitative computed tomography ( QCT) in human lumbar spine .Methods 121 patients with lumbocrural pain underwent volumetric bone mineral density measured by QCT at the site of lumbar spine ( L2~4 ) .According to the bone mineral density , all the subjects were divided into three groups:normal bone density group , osteoporosis group , osteopenia group .After routine MRI examination (Sagittal T2WI,T1WI and Axial T2WI),DWI was performed with single shot spin -echo planar imaging sequence ( b =0,600 s/mm2 ) and ADC values were measured .Finally the correlation between ADC and BMD was analyzed . Results There were no significant differences in ADC values among different male groups .As compared with those in normal bone density group,ADC values were significantly decreased in osteoporosis group [(0.2869 ±0.0475) ×10 -3 mm2/s vs (0.45 ±0.13) ×10 -3 mm2/s, P <0.01)] and in osteopenic group [(0.302 ±0.0677) ×10 -3 mm2/s vs (0.45 ±0.13) × 10 -3 mm2/s, P <0.01)] in females.ADC values were positively correlated with BMD values ( r =0.545, P <0.01) in females,but ADC values were not related to BMD values in males .Conclusion DWI can quantitatively evaluate osteoporosis noninvasively by observing the pathological changes of vertebral bone marrow at molecular movement level .
Keywords：bone densityosteoporosismagnetic resonance diffusion weighted imagingcomputed tomography
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 648-651 )