Expression and significance of phosphorylated protein kinase B,PI3K and PTEN protein in ovarian epithelial cancer

doi:10.3969/j.issn.1002-7386.2014.04.006

Abstract：Objective To analyze the expression and significance of phosphorylated protein kinase B (p-AKT),PI3K and PTEN protein in ovarian epithelial cancers and to investigate the correlation among them and the correlation between their expression and prognosis of patients with ovarian epithelial cancer .Methods The positive expression rates of p-AKT,PI3K and PTEN were detected by immunohistochemical method in 10 cases of normal ovarian tissues ,20 cases of ovary benign epithelial tumors and 60 cases of ovarian epithelial cancers .Results The positive expression rates of p-AKT and PI3K in normal ovarian tissues and ovary benign epithelial tumors were significantly lower than those in ovarian epithelial cancers , however,the positive expression rates of PTEN in ovarian epithelial tissues were significantly lower than those in normal ovarian tissues and ovary benign epithelial tumors ( P <0.01).The expression levels of p-AKT,PI3K and PTEN were closely correlated to clinical stage,differentiation degree of cancer cells ,pathological classification and lymph node metastasis ( P <0.01),however,which were not related to patient's age,histological type and ascites ( P >0.05).The expression of p-AKT was positively related to that of PI 3K in ovarian epithelial cancer ( r =0.552, P <0.01),however,the expression of p-AKT was negatively related to that of PTEN in ovarian epithelial cancer ( r =-0.497, P <0.01),and the expression of PI3K was negatively correlated to that of PTEN in ovarian epithelial cancer ( r =-0.535, P <0.01).Conclusion The overexpression of p-AKT and PI3K followed by absence of PTEN are involved in the pathogenesis and development of ovarian epithelial cancer.