Clinical significance of detection of plas ma D-dimer and lipoproteins levels before and after chemotherapy in patients with advanced colorectal cancer
Abstract：Objective To explore the clinical significance of detection of plasma D-dimer and lipoproteins levels before and after chemotherapy in patients with advanced colorectal cancer .Methods The plasma levels of D-dimer, high-density lipoprotein ( HDL ) , lipoprotein ( a ) were detected in 96 patients with advanced colorectal cancer who were subdivided into valid chemotherapy group and invalid chemotherapy group and 112 healthy subjects ( control group ) .These parameters were detected before chemotherapy and 4 treatment courses after chemotherapy in patients with advanced colorectal cancer,and the therapeutic effects were evaluated according to RECIST criterion .Results As compared with those in control group,the plasma levels of D-dimer and LP ( a) were significantly increased in patients with advanced colorectal cancer ( P <0.01),however,HDL levels were significantly decreased ( P <0.01).The plasma levels of D-dimer and LP (a) in valid chemotherapy group were significantly decreased after chemotherapy ( P <0.05 ), however, the levels of HDL were significantly increased ( P <0.01).In contrast to that,the plasma levels of D-dimer and LP (a) were significantly increased in invalid chemotherapy group ( P <0.05),however,HDL levels were significantly decreased ( P <0.01).Concluison The plasma levels of D-dimer and lipoproteins may provide basis for evaluating therapeutic effects before and after chemotherapy in patients with advanced colorectal cancer .
Keywords：colorectal cancerD-dimerlipoproteinschemotherapy
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 498-500 )