The significance of expression of EZH2,PCNA,P16 in gastric cancer and its correlation with patient’ s prognosis
Abstract：Objective To investigate the significance of expression of EZH 2, proliferating cell nuclear antigen (PCNA),P16 in gastric cancer tissues and its correlation with clinicopathological characteristics and prognosis of patients . Methods The expression levels of EZH2,PCNA,P16 were tested by immunohistochemistry in 62 cases of gastric cancer tissues and 52 cases of tumor-adjacent tissues , and patients ’ clinicopathological characteristics and follow-up data were collected.The correlation among the three kinds of proteins was analyzed , and the relationship between EZH 2 and clinicopathological characteristics as well as prognosis of patients was analyzed .Results The expression levels of EZH2 (69.35%) and PCNA (83.87%) in gastric cancer tissues were significantly higher than those (21.15%,38.46%) in tumor-adjacent tissues ( P <0.05),however,the expression levels of P16 (33.87%) in gastric cancer tissues were significantly lower than those in tumor-adjacent tissues (73.08%, P <0.05).The expression levels of EZH2 were positively correlated with those of PCNA in gastric cancer tissues ,however,the expression levels of EZH2 were negatively correlated to those of P16 ( P <0.05),moreover,there was no obvious relationship between the expression of PCNA and that of P 16 ( P >0.05).The overexpression of EZH2 was related to the depth of tumor infiltration,differentiation degree,clinical TNM stage, lymph node metastasis ( P <0.05).Prognosis analysis showed that that the survival duration in patients with overexpression of EZH2 was obviously shorter than that of patients with weak expression of EZH 2 ( P <0.05 ).Conclusion The overexpression of EZH2 appears in gastric cancer tissues , which is related to clinicopathological characteristics of gastric cancer,moreover,EZH2 protein can be served as an index of prognosis evaluation ,and its effect in gastric cancer may be correlated to regulating proliferation ability of tumor cells .
Keywords：gastric cancerenhancer of zeste homolog 2proliferating cell nuclear antigenP16 proteinclinicopathological characteristicsprognosis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 492-494 )