Expression of PTEN protein and PCNA in primary small bowel adenocarcinoma and Significancy
WU Xiaohua
ZHANG Shen
ZHOU Wenkuo
Abstract：Objective To detect PTEN protein and proliferatingcell nuclear antigen (PCNA) in primary small bowel adencareinoma(SBAC) tissue,adjacent nontumorons tissue,and normal small bowel tissue,to investigate the relationship between the expression of tumor suppressor gene PTEN protein and PCNA and the biologcal behaviors of primary small bowel adencareinoma.Methods Expression of PTEN protein and PCNA location were examined by streptavidin-peroxidase immunohistochemistry method in 32 SBAC,the corresponding adjacent nontumorons tissue and 8 normal small bowel tissues. Results Expression of PTEN protein was detected in 71.88% of the primary SBAC tissue,while expression in adjacent nontumorous tissue and normal small bowel tissue was detected in 15.63%and 12.50%( P <0.05).The positive expression of PTEN was significantly related to the cell differentiation ,diversion of ganglia lymphatica in primary SBAC tissue ( P <0.05).Expression of PCNA was detected in 65.63%of the primary SBAC tissue.6.25%of the adjacent nontumor tissue and 2.50%normal small bowel tissue ( P <0.05);The positive expression 0f PCNA was a significantly related to the tumor location,tumor infiltration depth and cell differentiation in primary SBAC tissue ( P <0.05).Conclusion Expression of tumor suppressor gene PTEN and PCNA could be helpful in predicting the biological behavior and prognosis of primary SBAC.
Keywords：adenearcinoma intestinesmallprotein PTENproliferating cell nuclear antigenimmunohistochemistryprediction
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 330-332 )