Animal experimental study on the correlation between chemokine CXCL12-CXCR4 and ovarian cancer
Abstract：Objective To investigate the correlation between chemokine CXCL 12-CXCR4 and ovarian cancer . Methods The three kinds of ovarian cancer cells including SKOV 3 transfected with plasmid ,SKOV3 transfected with vector and SKOV3 without transfection were cultured in vitro .The transplantation tumor models in nude mice were established by intraperitoneal injection with tumor cells,after they died naturally,the tumor amount in abdominal cavity,tumor size,ascites volume and mean survival time were observed in the 3 groups.Results There were significant differences in the mean survival time,the number and weight of transplantation tumor among three groups ( P <0.05).The higher the concentration of CXCL 12,the more transplantation tumor ,the more weight the tumors and the shorter the survival time would be .Conclusion The chemokine CXCL12-CXCR4 is related to pathogenesis of ovarian cancer at some extent , which may be one of pathogenic reasons and reflects severe degree of the disease at some extent .
Keywords：CXCL12CXCR4ovarian neoplasms
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 177-179 )