Effect of icariin on osteoporosis induced by retinoic acid in rats
Abstract：Obej ctive To investigate the effect of icariin on osteoporosis induced by retinoic acid in rats .Method s The rats were randomly divided into control group ,model group and icariin low -dose,middle-dose,high-dose group,with 10 rats in each group .The osteoporosis models in rats were established by giving icariin 70 mg/kg via gavage for two weeks .The rats in icariin groups were given icariin 50,100,200mg by gavage,respectively for 4 weeks.The related indexes about blood and bone,bone density,bone physical and biomechanical parameters were detected .Results As compared with those in model group,the levels of Ca2+,P3+in serum were increased,however,the concentrations of ALP were decreased in icariin groups (P <0.01).The levels of Ca2+,P3+,Hyp in bone were increased ( P <0.05 or <0.01),and bone density,wet weight,dry weight ,maximum bending force ,bending strength ,bending strength ,the end point of section elastic load in bone were increased in icariin groups ( P <0.01).Conclusion Icariin has preventive and the therapeutic effects at some extent on osteoporosis induced by retinoic acid in rats .
Keywords：icariinretinoic acidosteoporosis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 8-9,10 )