Effects of intranasal administration of testosteronep ropionate on the open field behaviors of femael rats

doi:10.3969/j.issn.1002-7386.2014.01.001

Abstract：Objectiev To investigate the effects of long-term intranasal administration of testosterone propionate on the central nervous system by analyzing the open field behavior of rats .Methods The open field test was used to analyze five types of behavioral patterns of female rats including static sniffing behavior ,exploratory behavior,thigmotaxis behavior,motor behavior and grooming behavior .Re sults After intranasal administration of testosterone propionate the static sniffing number of times in intact-T group were increased by 47%,as compared with those in intact group ( P <0.05).The number of times of climbing,rearing and sniffing behavior in intact T group were decreased by 43%,56%,40%,respectively,as compared with those in intact group ( P <0.05).The vertical activity,horizontal activity and the total path length in intact T group were decreased by 46%, 45%, 42%, respectively , as compared with those in intact group ( P <0 .05 ) .The latency time of grooming in intact T group was decreased by 84%,however,grooming events and the duration of grooming were increased by 48%,as compared with those in intact group ( P <0.05).Conclusion The long-term intranasal administration of testosterone propionate can increase static behaviors of female rats ,however,which can decrease the rats'activity behaviors in open field test .