The effect of atorvastatin on the expressionof Lkn-1d uring U937 monocyte differentiating into foam cells induced by oxid ized LDL
Abstract：Objetc ive To observe the effect of atorvastatin ( AT) on the expression of Lkn-1 during U937 monocyte differentiating into foam cells induced by oxidized LDL ( ox-LDL) ,and to explore the antiatherosclerotic action mechanism of AT .Method s The macrophages derived from U 937 monocytes were induced by PMA (0.1μmol/L),which were treated with 100mg/L ox-LDL plus different concentrations of AT (0.1,1,10μmol/L) for 24 hours.Then the expression levels of Lkn-1 in supernatant of cultured cell were detected by ELISA and RT-PCR.Results As compared with those in control group ,the expression levels of Lkn-1 of in ox-LDL group were significantly increased ( P <0.05).However the expression levels of Lkn-1 in different concentrations of AT groups were significantly decreased ,as compared with those in ox-LDL group ( P <0.05).Moreover with the increase of AT concentration, the the expression levels of Lkn-1 were gradually decreased ( P <0.05 ). Conclusion Atorvastatin can inhibit the expression and secretion of Lkn-1 in the course of U937 monocyte differentiating into foam cells induced by ox-LDL,which may be the action mechanism of AT in anti-atherosclerosis and in inhibiting inflammatory factor .
Keywords：atorvastatinfoam cellsLkn-1oxidized low density lipoproteinU937 cell line
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 3688-3690 )