Combined detectoi n of GPC3, TBA and GGT in application of diagnosis of primary hepatocellular carcinoma
Abstract：Objective To evaluate the clinical significance of combined detection of GPC 3, TBA andγ-glutamyl transpeptidase ( GGT ) in diagnosis of primary hepatocellular carcinoma ( PHC ) .Methods Forty-five patients with liver carcinoma ,43 patients with cirrhosis and 30 healthy subjects were enrolled in the study in our hospital from May 2010 to January 2011,and they were divided into PHC group ,cirrhosis group and control group.The levels of GPC3,TBA,GGT were detected by enzyme-linked immunosorbent assay ,cyclophorase assay,velocity method,respectively.R esults (1)There were significant differences in the levels of GPC3,TBA, GGT between PHC group and the other two groups ( P<0.01).There were significant differences in the levels of GPC3,TBA,GGT between cirrhosis group and control group ( P <0.01).(2)The positive rates of GPC3 and TBA in PHC group were significantly higher than those in cirrhosis group or control group ( P <0.01),however,there was no significant difference in positive rate of GGT between cirrhosis group and control group ( P >0.05).(3) The positive rate of combined detection of the three parameters was 97 .7%( 44/45 ) , and the positive rate of combined detection was superior to that of any single item detection ( P <0.05).Conclusion The combined detection of GPC3, TBA and GGT can enhance obviously positive rate of PHC , which has important clinical significance in early diagnosis of PHC .
Keywords：phosphatidylinositol proteoglycan 3total bile acidsγ-glutamyl transpeptidaseprimary hepatocellular carcinomasensitivityspecificity
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 3535-3536,3537 )