Expression and clinical significance of IGFBP-1 in early spontaneous abortion patients with polycystic ovary syndrome
HAO Ming
ZHOU Nan
WANG Qingqin
Abstract：Objective To investigate the expression and clinical significance of IGFBP1- in early spontaneous abortion patients with polycystic ovary syndrome .Methods 77 early spontaneous abortion patients with PCOS ( pregnant period <12 weeks ) were enrolled as experimental group , and 68 normal pregnant women ( pregnant period <12 weeks ) who asked for induced abortion were enrolled as control group .The levels of IGFBP-1,IGF-1,SHBG,fasting insulin,fasting glucose,total testosterone and free testosterone in peripheral vein blood were detected by ELISA respectively in 3 ~5 weeks,6 ~8 weeks,9 ~11 weeks after pregnancy for both groups.The expression levels of IGFBP-1 and IGF-1 in decidua tissue were detected by flow cytometry.Results As compared with those in control group ,the levels of fasting insulin in 3~5wk and 9~11wk and fasting glucose in 3~5wk were significantly increased in experimental group ( P <0.01),however,there were no significant differences in the levels of fasting insulin in 6 ~8wk and fasting glucose in 6 ~8wk and 9~11wk between experimental group and control group ( P >0.05).The levels of testosterone and free testosterone in the three experimental groups were significantly higher than those in control group ( P <0.01),however,the levels of IGFBP-1and SHBG were significantly lower than those in control group ( P <0.05 or <0.01).There were no significant differences in the levels of IGF-1 between experimental group and control group ( P >0.05).Takingβ-actin as interior reference , the expression levels of IGFBP-1 in decidua tissue in experimental group were significantly lower than those in control group ( P <0.05),however,the expression levels of IGF-1 in decidua tissue in experimental group were significantly higher than those in control group ( P <0.05).Conclusion The reduction of serum IGFBP-1 and SHBG concentrations and decrease of expression levels of IGFBP-1 and IGF-1 in decidua tissue of early spontaneous abortion patients with PCOS suggests that endometrial epithelial and stromal dysfunction may play an important role in the pathogenesis of early spontaneous abortion in patients with PCOS .
Keywords：IGFBP-1polgcystic ovary syndromeenzyme-linked immunosorbent assay
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 3525-3527 )