Expression and significance of NF-κB and MMP-9 in cervical carcinoma tissues before and after ;interventional chemotherapy

ZHAO Yuchan; LI Lian; ZHANG Lianmei

doi:10.3969/j.issn.1002-7386.2013.22.004

Abstract：Objective To investigate the expression and significance of NF-κB and MMP-9 in cervical carcinoma tissues before and after interventional chemotherapy ( IC).Methods The expression levels of NF-κB and MMP-9 were detected by immunohistochemistry method in 80 cases of cervical carcinoma ( CSES) before and after IC,70 cases of cervical intraepithelial neoplasm (CIN) and 50 cases of normal cervical tissues (NCE).The therapeutic effect of IC and the correlation between the expressions and clinical pathological characteristics before and after IC were observed and analyzed .Results Among CSES,CIN and NCE tissues,the positive expression rates of NF-κB and MMP-9 proteins were 72.5%,18.6%,0 and 68.8%,15.7%,0,respectively.The expression levels of NF-κB and MMP-9 in CSES were significantly higher than those in CIN and NCE ( P <0.05).The expression levels of NF-κB and MMP-9 were correlated to the degree of cell differentiation ,clinical stage and lymph node metastasis of cervical carcinoma ,however,which were not related with patient ’s age and histological type.The expression levels of NF-κB were positively correlated with those of MMP-9 ( r =0.872, P <0.05).The total effective rate of IC was 81.3%,moreover,the expression levels of NF-κB and MMP-9 after IC were significantly decreased ,as compared with those before IC .Conclusion The overexpression of NF-κB and MMP-9 exists in patients with cervical carcinoma and IC can significantly reduce the expression levels of NF-κB and MMP-9,as a result,which may inhibit the proliferation ,infiltration,invasion and metastasis of tumor cells .