Therapeutic effect and safety of regeneration formula on low-risk myelodysplastic syndromes
Abstract：Objective To observe the therapeutic effect and safety of regeneration formula on low-risk myelodysplastic syndromes ( MDS) .Methods Sixty patients with low-risk MDS who were inpatients or outpatients from February 2008 to July 2010 were enrolled in the study ,including 12 cases of RA ,42 cases of RCMD ,2 cases of RAS,4 cases of MDS-U according to the criterion of diagnosis and typing of WHO .These patients were randomly divided into treatment group ( n =30) and control group ( n =30).The patients in treatment group were treated with regeneration formula which was decocted in water for oral dose ,one dose a day ,however ,the patients in control group were treated with stanozolol ,2mg once,3 times a day.The patients were given antibacterials in case of infectious fever,and they were injected with red cell suspension or platelets in case of sever anemia or obvious hemorrhage ,meanwhile the transfusion amount of red cell suspension or platelets was calculated .Results The total effective rates in treatment group and control group were 66.7%,36.7%,respectively,there was a significant difference between two groups ( P <0.05 ).Cell morphous observation results showed that erythron dyshaematopoiesis was relieved in treatment group .There was a significant difference in transfusion amount of red cell suspension between two groups ( P <0.05),so was in transfusion amount of platelets ( P <0.05).The adverse reactions were taken place in 4 patients of treatment group , and the incidence rate was 20%, but these adverse reactions were all mild digestive tract reaction ,and no injury of liver and kidney was found .However the adverse reactions were taken place in 20 patients of control group ,and the incidence rate was 66.7%,there was a significant difference between two groups ( P <0.01).Concluison The regeneration formula is effective in treating low-risk MDS,and its effective rate is higher than that of stanozolol ,furthermore,which can reduce the transfusion amount of red cell suspension or platelets , without severe adverse reactions .The regeneration formula can also improve erythron dyshaematopoiesis ,as a result,improve obviously red blood cells and hemoglobin .
Keywords：myelodysplastic syndromeregeneration formulaTCM of invigorating kidneytcell morphology
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 3215-3217 )