The expression and clinical significance of PTEN and NF-κB in NSCLC tissues

BAO Zhenxue; MAO Guiling; LIU Yunyun

doi:10.3969/j.issn.1002-7386.2013.20.004

Abstract：Objective To detect the expressions of phosphatase and tensin homology deleted on chromosome ten (PTEN) and nuclear factor-κB (NF-κB) in non-small-cell lung carcinoma (NSCLC) tissues,and to explore their correlation with clinical pathological characteristics as well as patient ’ s prognosis .Methods The immunochemistry method was used to detect the expressions of PTEN and NF-κB in NSCLC tissues and adjacent nontumorous tissues.Results The positive rates of PTEN expression in lung cancer tissues were 24.42%(21/86),which were significantly lower than 72.09% (62/86) in adjacent nontumorous tissues ( P <0.05), however,the positive rates of NF-κB expression in lung cancer tissues were 63.95%( 55/83 ), which were significantly higher than 25.58%( 22/86) in paracancerous tissues ( P <0.05).The positive rates of PTEN and NF-κB expressions were related to clinical pathology staging ,differentiation degree of tissue and survival periods after operation,however,which were not correlated with gender ,age,smoking,tumor size and histological grading ( P >0.05),however,the expression of PTEN was negatively correlated to that of NF-κB ( rs =-11.30, P <0.05).Conclusion The inactivation of PTEN gene and activation of NF-κB gene may promote the pathogenesis , development,invasion and metastasis of lung cancer , which can be used as the indexes to evaluate tumor ’ s malignant degree and prognosis .