The expressions of Cox-2,β-catenin and Survivin in tongue carcinoma and their correlation
Abstract：Objective To investigate the expressions of cyclooxygenase-2(Cox-2),β-catenin and Survivin in tongue carcinoma in order to provide important clinical evidence for early diagnosis , therapy and prognosis of tongue carcinoma .Methods The expressions of Cox-2 mRNA,β-catenin mRNA and Survivin mRNA were detected by RT-PCR in 60 cases of primary tongue carcinoma and 30 cases of normal oral mucosa , and the difference of expressions and correlation among them were analyzed .Results The expressions Cox-2 mRNA and Survivin mRNA were strongly positive in tongue cancer ,however ,which were negative in normal oral mucosa ( P <0.01 );there was a significant difference in β-catenin expression quantity between tongue cancer and normal oral mucosa ( P <0.05).The expression quantity of Cox-2 mRNA,β-catenin mRNA and Survivin mRNA in poorly differentiated tongue cancer was significantly higher than that in well-differentiated and moderately-differentiated tongue cancer ( P <0.05 ).There was a positive correlation in their expressions in tongue cancer among Cox -2,β-catenin and Survivin ( P <0.01).Conclusion Cox-2,β-catenin and Survivin play an important role in the pathogenesis and development of tongue cancer , and there maybe a synergism among Cox-2,β-catenin and Survivin .
Keywords：tongue carcinomaCox-2β-cateninSurvivinRT-PCR
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 2893-2895 )