The expression of p27 protein in gingival cancer and precancerous lesions tissues and its clinical pathological significance
YAN Wei
CHEN Yong
LI Haobo
Abstract：Objective To investigate the expression of cell cycle related protein p 27 in gingival cancer and oral precancerous lesions tissues as well its clinicopathological significance .Methods The experimental levels of p27 protein were detected by immunohistochemistry ( SP) in 21 cases of normal mucous membrane tissues ,26 cases of oral precancerous lesions tissues ( leukoplakia , erythema ) and 46 cases of gingival cancer tissues .The correlation between p27 protein and pathological classification , clinical stage of gingival cancer was analyzed . Results There were significant differences in the positive rates and positive expression rates among normal mucous membrane tissues,precancerous lesions tissues and gingival cancer tissues ( P <0.05).The expression levels of p27 protein in normal mucous membrane tissues were higher than those in the other two groups , which were not related with patient ’s gender and age ( P >0.05),however,which were closely correlated with clinical stage and pathological classification of gingival cancer ( P <0.05).Conclusion The p27 protein is closely related to the pathogenesis and development of precancerous lesions and gingival cancer , which is negatively correlated with clinical stage ,however ,which is positively related to pathological classification of gingival cancer .
Keywords：gum cancerp27cell cycleimmunohistochemistry
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 2887-2889 )