Correlation between Y chromosome structure polymorphism in males and clinical effects
Abstract：Objective To investigate the relationship between Y chromosome structure polymorphism in males and clinical effects .Methods Y chromosome abnormality was examined and analyzed by conventional cytogenetic technology .Results A total of 46 cases were examined ,in which there were 13 cases of Y-chromosome polymorphism variation,and the mutation detection rate was 28.26%(13/46).Among them there were 10 cases of big Y chromosome,and the paragenesis rate was 21.74%,which was significantly higher than that in normal population( P <0.01),and there were 2 cases of del(Y),with abnormal rate being 4.35%,and there was 1 cases of t (Y;15),with abnormal rate being 2.17%.Conclusion Y-chromosome polymorphism is related to clinical diseases,including male infertility,male sterility,and his wife with habitual abortion,and stillbirth,stillbirths,infant deformities,mental retardation infants and so on .
Keywords：Y chromosome polymorphismcytogeneticskaryotype analysisclinical effect
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 2576-2577 )