Effect of LED red light irradiation on blood lipid in rats with hyperlipidemia

doi:10.3969/j.issn.1002-7386.2013.17.003

Abstract：Objective To observe the effects of light emitting diode [LED,(630 ±15)nm] on blood lipid and pathological changes of liver in rats with hyperlipidemia .Methods Thirty-six male Sprague-Dawley rats were randomly divided into control group ( n =12 ) and hyperlipidemia model group ( n =24 ) .The rats in control group was kept on feeding with normal diet ,however ,the rats in hyperlipidemia model group were fed with fat-rich forage for six weeks .After the hyperlipidemia models were established ,the rats were randomly divided into hyperlipidemia control group and LED treatment group .The rats in LED treatment group were given LED red light irradiation for 28 days.The levels of blood lipid including total cholesterol (TC),triglyceride (TG),low-density lipoprotein (LDL-C),high-density lipoprotein (HDL-C) were detected by biochemical assay at the 15th day and 29th day.The animals were sacrificed at the 29th day and their livers were taken out for gross and microscopic examination.Results After 14-day irradiation,the serum levels of TC,TG,LDL-C in LED treatment group were decreased,but the serum levels of HDL-C were significantly increased ,as compared with those in hyperlipidemia control group,and there was a significant difference in serum levels of LDL-C between the two groups ( P <0.05).After treated with LED for 28 days,the serum contents of TC,TG and LDL-C were significantly decreased, while the serum levels of HDL-C were increased significantly , as compared with those in control group ( P <0.01).The liver weight and liver index were also significantly decreased ( P <0.01 ).The degree of fatty degeneration of liver in LED treatment group was obviously relieved ,as compare with that in hyperlipidemia model group.Conclusion LED red light irradiation can significantly decrease blood lipid levels and has certain therapeutic effect on fatty degeneration of liver in rats with hyperlipidemia .