Study on the Protective Effect and Mechanism of Selenomethionine Against Nonalcoholic Steatohepatitis
ZHANG Peipei
LUO Kai
Abstract：To investigate the interventional effect of selenomethionine(SeMet)in nonalcoholic steatohepatitis(NASH),a mouse model of NASH was established using a choline-deficient,amino acid-defined(CDAA)diet,followed by SeMet intervention via gavage.The results showed that SeMet intervention significantly alleviated hepatic steatosis and inflammation,and improved serum liver function and lipid profiles.It also promoted the recovery of beneficial gut microbiota,such as Akkermansia muciniphila and the Dubosiella genus,while suppressing the expansion of conditional pathogens like Enterococcus.At the molecular level,SeMet markedly upregulated the messenger ribonucleic acid(mRNA)expression of key hepatic antioxidant selenoproteins and reversed the CDAA diet-induced downregulation of short-chain fatty acid receptors.These findings suggested that SeMet might protect against NASH by cooperatively regulating the thioredoxin reductase(TXNRD)and glutathione peroxidase 4(GPX4)antioxidant pathways along with the"gut microbiota-short-chain fatty acid receptor"signaling axis,thereby providing a theoretical basis for its development as a functional dietary component.
Keywords：selenomethioninenonalcoholic steatohepatitisselenoproteinoxidative stressgut microbiota
Publication Date：2026-03-20
Online Publishing Date：2026-03-26(First online date of this platform, not the publication date of the document)
Pages：7( 29-34,81 )