Study on the Antioxidant Activity of Idesia polycarpa Maxim.Oil and Its Effect on Lipid Accumulation in HepG2 Nonalcoholic Fatty Liver Disease
HE Huahan
ZHANG Shiyi
LUO Kai
Abstract：In order to improve application value of Idesia polycarpa Maxim.oil,based on investigating the antioxidant activity of Idesia polycarpa Maxim.oil,oleic acid(OA)was used to induce human hepatocellular carcinoma(HepG2)cells to establish an in vitro high-fat nonalcoholic fatty liver disease(NAFLD)model,and effects of Idesia polycarpa Maxim.oils on lipid accumulation in the NAFLD model of HepG2 cells were carried out.The results showed that cold-pressed Idesia polycarpa Maxim.oil showed its strong antioxidant capacity,and had a significant effect on the size and number of lipid droplets in NAFLD model of HepG2 cells and the degree of cellular damage.The contents of triglyceride(TG)and total cholesterol(TC),the activities of aspartate transaminase(AST)and alanine transaminase(ALT)in the treated HepG2 cells were significantly decreased.Idesia polycarpa Maxim.oil had a significant mitigating effect on OA-induced fatty degeneration of liver in HepG2 cells by enhancing antioxidant activity,reducing liver injury,and regulating lipid metabolism.The results provided a scientific basis for the development and utilization of as a functional lipid.
Keywords：Idesia polycarpa Maxim.oilantioxidantliver injurylipoatrophylipid metabolismlipid accumulation
Publication Date：2025-03-19
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：9( 25-33 )