Enhancing Effect of Acaudina leucoprocta Peptide on Cyclophosphamide-induced Immune Hypofunction in Mice
FU Shiqing
YANG Xu
WANG Jiaoyan
YU Fangmiao
Abstract：Cyclophosphamide(CTX),a broad-spectrum anticancer drug,kills cancer cells but also induces immunocompromise.The ameliorative effects of Acaudina leucoprocta peptides(ALPs)on CTX-induced immunocompromise in mice were investigated.Sixty male ICR mice were randomly divided into the normal group,model group(CTX),ALPS-L group(CTX+50 mg/kg ALPs),ALPS-M group(CTX+100 mg/kg ALPs),and ALPS-H group(CTX+200 mg/kg ALPs).An immunocompromised mouse model was established by administering CTX intraperitoneally for 5 days,followed by ALP administration for 19 days,after which the changes in immune indices and morphological changes of immune organs were detected.The results showed that the body weight of the high-dose ALP group increased to 36.10 g,which was only 0.37 g higher than that of the model group.The thymus and spleen indices were significantly increased(P<0.01),and the spleen morphology tended toward normal.The synthesis of nitric oxide(NO)in peritoneal macrophages,the level of serum hemolysin,and the activity of natural killer(NK)cells significantly increased(P<0.01).In addition,ALPs significantly increased the levels of cytokines and immunoglobulins in the serum of mice(P<0.01),and the levels of interleukin-1β(IL-1β)in the medium and high dose groups increased by 1.60 and 1.62 times,respectively.In conclusion,ALPs effectively ameliorated CTX-induced immunocompromise in mice and may serve as a natural source of immune enhancers.
Keywords：Acaudina leucoproctaactive peptidecyclophosphamideimmune regulation
Publication Date：2026-01-20
Online Publishing Date：2026-03-31(First online date of this platform, not the publication date of the document)
Pages：8( 9-16 )