Evaluation of Alcohol Detoxification and Liver Protection Effects of Different Food-derived Compounds
LAI Xi
WU Junlin
CHEN Chun
FU Xiong
Abstract：This study aimed to evaluate the alcohol detoxification and liver protection effects of seven food-derived compounds(samples 1 to 7)using an acute alcoholic liver injury model in mice induced using 0.14 mL/10 g of 56° liquor.After treatment,behavioral changes were observed,and the blood alcohol concentration,activity of key alcohol-metabolizing enzymes,biochemical indicators of liver injury,and histopathological morphology of the liver were determined.Treatment with sample compounds reduced the intoxication rate in all groups(lowest percentage:33.33％),extended the intoxication time by up to 54.03％,and shortened the time to regain the righting reflex by up to 31.65％.The lowest blood alcohol concentration among the groups was observed at 1 h and 4 h in mice treated with sample 2(30.17 and 3.79 μmol/L,respectively).The alcohol dehydrogenase activity in mice treated with sample 2 and the aldehyde dehydrogenase activity in mice treated with sample 1 were reduced by 31.92％and 30.40％,respectively.The levels of serum aspartate aminotransferase and alanine aminotransferase in mice treated with sample 5 significantly decreased by 23.87％and 39.87％,respectively.The malondialdehyde content in mice treated with sample 1 decreased by 29.66％,and the total superoxide dismutase content in mice treated with sample 2 increased by 52.94％.Histopathological examination revealed that treatment with the sample compounds improved the alcohol-induced abnormal cell structure and fat vacuolation in the liver.In conclusion,the seven food-derived compounds had significant alcohol-detoxifying and liver protection effects,through mechanisms partially related to enhancing the activity of alcohol-metabolizing enzymes and improving liver antioxidant capacity.Moreover,the differential effects of the food-derived compounds are related to the ratio of their total sugar and phenolic content,with samples 1 and 2 showing the best effects.The results of this study provide a theoretical basis for further developing and utilizing natural products for alcohol detoxification and liver protection.
Keywords：acute alcoholic liver injuryfood-derived compoundalcohol detoxificationliver protection
Publication Date：2025-05-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：9( 10-18 )