Anti-glycation Effects of Lumenato Extract Complex and Its Anti-aging Effects in Mice
LIU Huiping
LIU Hongji
LI Shaofei
CHEN Xiao
JIANG Liang
FENG Dongliang
LUO Zhenhua
LUO Jieling
LIAO Wenzhen
Abstract：The anti-glycation,antioxidant,and anti-aging effects of Lumenato extract complex were examined by establishing in vitro anti-glycation and antioxidant models and an in vivo model of aging in mice,respectively.The results revealed that the application of the extract complex at a concentration of 0.2 mg/mL resulted in inhibition rates of 44.39％,19.22％,and 69.28％were for fructosamine,active carbonyl compounds,and fluorescent advanced glycation end-products,respectively.Furthermore,the anti-glycation effects of the complex were found to be superior to those of aminoguanidine,and the complex exhibited significant scavenging effects on O2-·,OH,and ABTS+·(in the order ABTS+·＞·OH＞O2-·).In addition,cell experiments revealed that the complex can significantly reduce the cytotoxicity of methylglyoxal and enhance the viability of HepG2 cells(P＜0.05).In the mouse aging model,the complex alleviated the liver injury induced by D-galactose,as well as restored liver total superoxide dismutase levels(P＜0.05).These findings thus provide evidence indicating that with respect to its anti-glycation,antioxidant,and anti-aging properties,Lumenato extract complex has promising application potential in the functional food and health product industries.
Keywords：advanced glycation end-productLumenato extractanti-glycationanti-aging
Publication Date：2024-11-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：10( 87-96 )