Effect of Atractylodes Decoction Prescription on Regulating Gut Flora and Protecting Intestine

ZENG Hong-liang; XIAO Man; CHEN Bo; ZENG Wen-bin

doi:10.13982/j.mfst.1673-9078.2018.1.005

Abstract：Effects of Atractylodes Decoction prescripton on regulating gut flora and protecting intestine were investigated in this study.After treatment with Atractylodes Decoction prescription for 30 days,compared with pre-treated animals,the intestinal Escherichia coli in high-dose group and enterococcus in middle-and high-dose groups were significantly decreased by 8.17％,6.35％ and 5.69％,respectively.Conversely intestinal bifidobacteria and lactobacillus in middle-and high-dose groups were increased significantly by 7.04％,6.74％,6.99％ and 8.10％,respectively.Furthermore,when compared with galactooligosaccharide (GOS) group,the effect of Atractylodes Decoction prescription on intestinal bifidobacteria and lactobacillus were also significantly increased.But the pH value of cecal contents in middle-dose and high-dose groups were noticeably reduced by 6.58％ and 5.26％,respectively.In the histopathological examination of intestinal tract,the ratio of the villus length to the corresponding crypt depth (A/V ratio) of duodenum and ileum in low-dose group,A/V ratio of duodenum,jejunum and ileum in middle-and high-dose groups,were markedly improved by 29.84％,17.47％,56.01％,31.18％,20.09％,46.51％,30.52％ and 20.09％,respectively.In addition,the AN ratio of the jejunum and ileum in middle-and high-dose groups were markedly increased when compared with the GOS group.In addition,the intestinal propulsion rates in treated animals were dose-dependently promoted by 43.92％,69.93％ and 98.31％,respectively.These data demonstrated that Atractylodes Decoction prescription improve intestinal microenvironment by regulating intestinal flora and showed improving effects when compared with GOS alone.