Inhibitory Effects of Ingredients of Fructus schisandrae on the α-glucosidase Activity
QIU Ming-yang
TIAN Shuang
ZHAO Wu
LIU Yu-ting
GONG Pei-han
YAN Ming-ming
SHAO Shuai
Abstract：The inhibitory effects of total lignans,total flavone,total triterpenes,schisandrol B,deoxyschizandrin,schisandrin and schisantherin A of Fructus schisandrae on the α-glucosidase activity.Using the in vitro inhibition of α-glucosidase activity as a model and 4-nitrophenyl α-D-glucopyranoside (PNPG) as substrate as well as acarbose (ACAR) as a positive control,the inhibitory effects of total lignans,total flavone,total triterpenes,schisandrol B,deoxyschizandrin,schisandrin and schisantherin A of Fructus schisandrae on the activity of α-glycosidase were determined in vitro.When the concentrations of total lignan,total flavone and total triterpenes in Fructus schisandrae were 1.0 mg/mL,the inhibitory rates of α-glucosidase were 96.15±1.52％,60.33±1.84％ and 48.62±2.15％,respectively.When the concentrations of schisandrol B,deoxyschizandrin,schisandrin and schisantherin A were of 0.33 mg/mL,the inhibitory rates of α-glucosidase were 96.53±1.62％,68.48±1.83％,15.57±2.37％,6.24±2.49％,respectively.The total lignans and schisandrin B in Fructus schisandrae had a significant inhibitory effect on the activity of α-glucosidase,and had a significant dose-effect relationship.
Keywords：Fructus schisandraeactive ingredientsα-glucosideaseinhibitory effect
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 104-108 )