The Antioxidant and Antityrosinase Activities of Carvacrol
ZHANG Ling-zhi
XU Jia
SHU Qing-long
SHAO Wen-xiang
LIU Sheng-zhang
ZUO Ai-ren
Abstract：The antioxidant and antityrosinase activities of carvaerol was investigated by scavenging 1,1-diphenyl-2-picrylhydrazyl (DPPH),2,2'-azinobis-(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS),hydroxyl radical (·OH) and superoxide radicals,inhibiting lipid peroxidation and inhibiting tyrosinase activity.The experiment results showed that carvaerol had excellent antioxidant and antityrosinase activities in dose-dependent manner.In the experiments of scavenging DPPH,ABTS,·OH and superoxide radicals,inhibiting lipid peroxidation and inhibiting tyrosinase activity,the IC50 of carvacrol were 100 μmol/L,18.18 μmol/L,16 μmol/L,16 μmol/L,12.5 μmol/L and 6.67 μmol/L,respectively.The IC50 of kaempferol used as the positive control drug were 80 μtmol/L,9.09 μmol/L,12 μmol/L,12 μmol/L,8.33 μmol/L and 3.33 μmol/L,respectively.Carvacrol had one phenolic hydroxyl group,while kaempferol had three phenolic hydroxyls.The different molecular structures led to the different antioxidant and antityrosinase activities.In a word,carvacrol had good antioxidant and antityrosinase activities,worth being further researched as the new anti-aging candidate drug,cosmetic materials and food additives.
Keywords：carvacrolhydroxyl radicalsuperoxide radicallipid peroxidationantityrosinase
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 84-88 )