Toxicological Safety Evaluation of Royal Jelly Acid Lyophilized Powder
BAI Bing-yao
ZHOU Qian
YANG Guang
DONG Xiao-han
YAN Chen-jing
HAN Xue
CAI Dong-wei
ZHAO Wen
Abstract：The safety of lyophilized powder of royal jelly acid was studied for the reasonable utilization and development of eleutheroside.According to the national standard procedures and methods in food safety and toxicological evaluation,a series of toxicological studies on the ingestion of eleutheroside were conducted,including the acute oral toxicity test in mice,genetic toxicity tests (salmonella typhimurium reverse mutation test (Ames test),mouse bone marrow cell micronucleus test and mouse sperm malformation test) and a 30-day feeding test in rats.Oral acute toxicity test showed that the medium lethal dose (LD50) of the powder was above 20 mg/kg·bw for both male and female mice.The results of Ames test,mouse bone marrow micronucleus test and spermabnorinality test were negative.The 30-day feeding test showed that the physical appearance and indices of hematology,biochemistry,organ coefficients and histological observations of rats had no significant differences as compared with the control group.
Keywords：royal jelly acidtoxicology evaluationacute toxicity testgenotoxicity test30-day feeding test
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 102-109 )