Anti-inflammatory Activity of Extract M of Plant Combinations in SD Rats
GAO Qing
REN Ying-lang
GE Ya-zhong
YOU Li-jun
Abstract：Sprague-Dawley (SD) rats were used as the experimental model in this paper whereby an SD rat model of inflammation was established by implanting cotton ball.Further,the effects of extract M of plant combinations on the body weight,food intake,and water intake of rats with cotton-ball-induced inflammation were studied.Enzyme-linked immunosorbent assay (ELISA) was employed to study the effects of extract M of plant combinations on the secretion of inflammatory mediators and synthetic pathways ofprostaglandin E2 and leukotriene in rats with cotton-ball-induced inflammation.The results showed that extract M had no significant effects on the body weight,food intake,and water intake of normal SD rats,however had a certain impact on the food intake of rats after the model of inflammation was established.Extract M could significantly alleviate the excessive secretions of C-reactive protein,nitric oxide,arachidonate 5-1ipoxygenase,and leukotriene C4 in the inflammation reaction,and had no significant inhibitory effects on the secretions of interleukin-lβ,tumor necrosis factor-α,prostaglandin E2,and cyclooxygenase 2.The above findings indicated that extract M of plant combinations exerted anti-inflammatory effects by inhibiting the synthesis of leukotriene C4 by arachidonate 5-1ipoxygenase and therefore can contribute to anti-inflammatory applications.
Keywords：granulomasinflammationleukotrieneprostaglandin
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 18-23,50 )