Hypoglycemic Effect of Polysaccharide from Acanthopanax Trifoliatus (Linn.) Merr.Stem in Streptozotocin-induced Diabetic Mice
YANG Hui-wen
ZHOU Lu
ZHANG Xu-hong
ZHOU Xiao-ming
CHENG Xuan-xuan
PAN Yu-fang
Abstract：The anti-hyperglycemic effect of polysaccharides from Acanthopananx trifoliatus (L.) Merr.stem (ATMP) was investigated in streptozotocin (STZ)-induced diabetic mice.These mice were divided into six groups,a normal group,a high blood glucose group,a metformin group,an ATMP low-dose [50 mg/(kg·d)] group,an ATMP middle-dose [100 mg/(kg·d)] group,and an ATMP high-dose [200 mg/(kg·d)] group.Four weeks after dosing by intra-peritoneal injection,body weight,organ index,blood glucose,and oral glucose tolerance were examined for all groups,and morphological changes were determined by HE staining.The polysaccharides at doses of 100 mg/(kg·d) and 200 mg/(kg·d) decreased blood glucose significantly by 47.73％ and 53.52％,respectively,and increased oral glucose tolerance.The AUC of mice in the 100 mg/(kg.d) and 200 mg/(kg·d) ATMP group were significantly lower than those in the high blood glucose group.ATMP at these doses also increased the thymus index by 48.9％ and 51.1％,respectively.HE staining showed that ATMP had a therapeutic effect on the pancreas and spleen.The results showed that ATMP has an anti-hyperglycemic effect,and this may occur through some form of immune regulation.
Keywords：Acanthopanax trifoliatus (Linn.) Merr.polysaccharidediabeticblood glucosemetformin
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 52-57 )