Clinical value of RAR and MHR in predicting postoperative recurrence after TURBT in NMIBC patients
Wang Wei
Chen Na
Zhang Yanhong
Zhang Jie
Qin Meishan
Li Hao
Cui Ying
Abstract：Objective To investigate the clinical value of the red blood cell distribution width-to-albumin ratio(RAR)and the monocyte/high-density lipoprotein cholesterol ratio(MHR)for predicting recurrence after transurethral resection of bladder tumor(TURBT)in high-risk non-muscle-invasive bladder cancer(NMIBC)patients,thereby providing a reference for indi-vidualized treatment and follow-up strategies for high-risk NMIBC.Methods A total of 128 high-risk NMIBC patients who underwent TURBT at Beijing Friendship Hospital,Capital Medical University from April 2022 to April 2024 were enrolled and followed for 6 months.According to recurrence during follow-up,patients were assigned to a recurrence group(n=31)and a non-recurrence group(n=97).Baseline data,clinicopathological features,and laboratory results were collected,and RAR and MHR were calculated.Receiver operating characteristic(ROC)curves were used to evaluate the ability of RAR and MHR to predict postoperative recurrence;multivariate stepwise logistic regression was used to analyze factors affecting postoperative recurrence among high-risk NMIBC patients after TURBT.Results RAR and MHR were significantly higher in the recurrence group than in the non-recurrence group(P<0.05).The AUC(95%CI)for RAR,MHR,and their com-bination to predict postoperative recurrence in high-risk NMIBC were 0.794(0.749-0.844),0.859(0.814-0.904),and 0.923(0.878-0.973),respectively.The AUC of RAR combined with MHR was significantly higher than that of either single marker(Z=8.749,10.604;P<0.05).Multivariate stepwise logistic regression analysis showed that multiple tumors(OR=2.246,95%CI:1.214-4.156),pathological T stage T1(OR=2.614,95%CI:1.484-4.606),RAR≥5.91(OR=2.986,95%CI:1.655-5.387)and MHR≥0.50(OR=3.121,95%CI:1.757-5.542)were independent risk factors for postoperative recurrence in high-risk NMIBC patients after TURBT(P<0.05).Conclusion Elevated RAR and MHR are closely associated with postoperative recurrence in high-risk NMIBC patients after TURBT,and both indica-tors have predictive value for recurrence;combined detection yields higher predictive performance.
Keywords：Red blood cell distribution width/albumin ratioMonocyte/high-density lipoprotein cholesterol ratioNon-mus-cle-invasive bladder cancerTransurethral resection of bladder tumor
Publication Date：2025-12-20
Online Publishing Date：2026-03-09(First online date of this platform, not the publication date of the document)
Pages：7( 84-90 )