Research progress on changes in cerebral blood flow and cerebral oxygen saturation in preterm infants with intraventricular hemorrhage
Ouyang Shanhong
Wei Wei
Li Wenlin
Zhuang Taiping
Yang Hui
Lin Shiping
Yao Chenyang
Abstract：Preterm neonatal brain injury is one of the common and difficult clinical conditions in neonatology,among which intraventricular hemorrhage(IVH)is the most frequent.IVH not only markedly affects neurological development in affect-ed infants but also increases mortality risk,imposing a heavy burden on families and society.Recently,with continuous im-provements in perinatal medicine,the mortality of preterm infants with IVH has decreased to some extent,yet long-term neurodevelopmental outcomes remain unsatisfactory.The pathogenesis of IVH is complex and involves immature cerebro-vascular development,disturbances in cerebral blood flow(CBF)hemodynamics,coagulation disorders,oxidative stress in-jury,and other factors.Among these,dysregulation of CBF hemodynamics is widely regarded as a key link in the initiation and progression of IVH,and abnormal changes in CBF and regional cerebral oxygen saturation(rSO2)are considered critical early-warning indicators of IVH risk.Clinically,continuous monitoring of CBF and rSO2 enables dynamic assessment of the condition of pediatric patients with IVH,helps early identification of disease progression,and allows timely adjustment of treatment strategies,thereby maximizing protection of infant survival and improving clinical prognosis.Therefore,this arti-cle summarizes the change patterns of CBF and rSO2 changes in preterm infants with IVH and reviews recent applications of CBF and rSO2 monitoring in these patients,with the aim of providing a reference for early identification and clinical diagno-sis and treatment of IVH.
Keywords：Preterm infantIntraventricular hemorrhageCerebral blood flowRegional cerebral oxygen saturationChange patternsEarly identificationMonitoring techniquesClinical intervention
Publication Date：2025-11-20
Online Publishing Date：2026-03-13(First online date of this platform, not the publication date of the document)
Pages：6( 151-156 )