Serum IL-33 and CHI3L1 levels and their relationship with post-stroke cognitive impairment and recurrence risk in elderly ischemic stroke patients
Han Wenxiu
Xing Ziyu
Wulanna
Jimusi
Yan Jun
Jin Zhu
Hao Lixia
Abstract：Objective To investigate the relationship between serum interleukin-33(IL-33)and chitinase-3-like protein 1(CHI3L1)level changes and the occurrence of post-stroke cognitive impairment(PSCI)and recurrence risk in elderly pa-tients with ischemic stroke(IS).Methods Ninety-eight elderly IS patients treated at the Affiliated Hospital of Inner Mon-golia Medical University from July 2021 to July 2024 were enrolled.Cognitive function was assessed at 3 months after IS on-set.Patients were divided into PSCI group and non-PSCI group according to whether PSCI occurred.At 12 months after IS onset,head CT/MRI was reexamined and patients were classified as recurrent or non-recurrent according to the presence of new ischemic lesions.Serum IL-33 and CHI3L1 levels were measured,and their relationships with PSCI occurrence and IS recurrence risk were analyzed.Results Multivariate logistic regression analysis showed that lesion location in functional are-as,low IL-33 level and high CHI3L1 level were risk factors for PSCI(P＜0.05).Receiver operating characteristic(ROC)curve analysis yielded AUCs of 0.732 and 0.763 for IL-33 and CHI3L1,respectively,in assessing PSCI,while the regres-sion model produced an AUC of 0.866.Multivariate logistic regression analysis indicated that higher National Institutes of Health Stroke Scale(NIHSS)score,low IL-33 level and high CHI3L1 level were risk factors for IS recurrence(P＜0.05).ROC curve analysis for IS recurrence produced AUCs of 0.760 and 0.815 for IL-33 and CHI3L1,respectively,and the re-gression model AUC was 0.899.Conclusion Abnormal changes in IL-33 and CHI3L1 levels in elderly IS patients are asso-ciated with the occurrence of PSCI and with increased risk of IS recurrence;their level changes may be useful as adjunctive assessments in clinical practice.
Keywords：Ischemic strokeChitinase-3-like protein 1Interleukin-33Cognitive impairment
Publication Date：2025-11-20
Online Publishing Date：2026-03-13(First online date of this platform, not the publication date of the document)
Pages：7( 25-30,80 )