Impact of mindfulness-based stress reduction on disease uncertainty and psychological distress in patients with acute leukemia

Hao Yanqing; Chen Ningping; Xing Shuangshuang; Kong Yilin; Xu Zhiting; Wang Menglan; Xu Lei

doi:10.11986/j.issn.1673-873X.2025.08.19

Abstract：Objective To explore the intervention effects of mindfulness-based stress reduction(MBSR)on disease uncertain-ty and psychological distress in patients with acute leukemia,with the aim of providing a reference for optimizing nursing in-tervention strategies for acute leukemia patients.Methods A total of 160 acute leukemia patients treated at the First Affili-ated Hospital with Nanjing Medical University from August 2023 to September 2024 were selected and randomly assigned to a control group and a study group,with 80 patients in each group.The control group received conventional therapy,while the study group received conventional therapy combined with MBSR intervention.Managing Uncertainty in Illness Scale(MUIS),psychological distress,quality of life,and degree of satisfaction with nursing were compared between the two groups before and after the intervention.Results Before intervention,there were no statistically significant differences be-tween the two groups in the two subscales(disease ambiguity and disease complexity)and total scores of the MUIS(P＞0.05).After intervention,the subscale and total scores of MUIS in both groups were lower than before the intervention,with the study group showing lower scores than the control group,and the differences were statistically significant(P＜0.05).Before intervention,there were no statistically significant differences between the two groups in psychological dis-tress,as measured by the Psychache Scale(PAS)and the Connor-Davidson Resilience Scale(CD-RISC;P＞0.05).After intervention,PAS scores in both groups were lower than before intervention,with the study group showing lower scores than the control group,and CD-RISC scores were higher than before the intervention,with the study group showing higher scores than the control group;these differences were statistically significant(P＜0.05).Before intervention,there were no statistically significant differences between the two groups in the four subscales(physical function,psychological function,social function,and material life)of the Generic Quality Of Life Inventory-74(GQOLI-74;P＞0.05).After intervention,the GQOLI-74 scores for each subscale were higher than before the intervention in both groups,with the study group show-ing higher scores than the control group,and the differences were statistically significant(P＜0.05).The overall degree of satisfaction with nursing in the study group was 91.25％(73/80),which was significantly higher than the 73.75％(59/80)in the control group(x2=8.485,P=0.004).Conclusion MBSR applied to nursing interventions for patients with acute leukemia can effectively reduce disease uncertainty and psychological distress,promote psychological resilience,improve quality of life,and increase the degree of satisfaction with nursing,making it worthy of clinical promotion.