Predictive efficacy of serum hs-CRP,Hcy,and NLR for in-stent restenosis after PCI in coronary heart disease patients
Li Jinyu
Zhang Ke
Feng Baobao
Li Tao
Song Yiming
Guo Shuangshuang
Zhou Yi
Abstract：Objective To analyze the predictive efficacy of serum high-sensitivity C-reactive protein(hs-CRP),homocysteine(Hey),and neutrophil-to-lymphocyte ratio(NLR)for in-stent restenosis(ISR)after percutaneous coronary intervention(PCI)in coronary heart disease patients.Methods A total of 105 coronary heart disease patients who underwent PCI with at least one drug-eluting stent(DES)at a hospital in Shandong province from February 2022 to October 2024 were enrolled.Based on the presence or absence of ISR occurrence within 6 months post-PCI,patients were assigned to ISR(n=13)and non-ISR(n=92)groups.General data and admission serum hs-CRP,Hcy,and NLR were compared.Logistic regression analysis was used to analyze independent correlations of hs-CRP,Hcy,and NLR,and receiver operating characteristic(ROC)curves were em-ployed to evaluate the predictive efficacy of combined detection of hs-CRP,Hcy,and NLR.Results No significant differences were found in gender,age,body mass index(BMI),left ventricular ejection fraction(LVEF)score on admission,or proportions of hypertension,dyslipidemia,smoking history,or multi-vessel disease between groups(P＞0.05).Admission serum hs-CRP([3.51±1.22]mg/L vs.[2.03±0.98]mg/L),Hcy([16.88±3.85]μmol/L vs.[12.57±3.01]μmol/L),and NLR(3.62±1.15 vs.2.38±0.91)were significantly higher in the ISR group than in the non-ISR group(P＜0.05).Multivariate analysis showed hs-CRP(OR=1.550,95％CI:1.087-2.209),Hey(OR=1.190,95％CI:1.031-1.373),and NLR(OR=1.820,95％CI:1.098-3.018)on admission were independent risk factors of ISR(P＜0.05).ROC curves demonstrated that combined hs-CRP,Hcy,and NLR prediction achieved 92.30％sensitivity and 87.00％specificity,with an area under the curve(AUC)of 0.947(95％CI:0.899-0.995).Conclusion Elevated serum hs-CRP,Hcy,and NLR on admission are independent risk factors for ISR within 6 months post-PCI in coronary heart disease patients.Combined detection offers high predictive value for ISR,providing refer-ences for preoperative risk assessment.
Keywords：Coronary heart diseasePercutaneous coronary interventionIn-stent restenosisHigh-sensitivity C-reactive pro-teinHomocysteineNeutrophil-to-lymphocyte ratio
Publication Date：2025-07-20
Online Publishing Date：2025-11-19(First online date of this platform, not the publication date of the document)
Pages：6( 26-31 )