Evaluation value of LTBP-2 and PON-1 levels on the condition and acute exacerbation in children with bronchial asthma
Yin Yue
Li Ruohan
Chai Xiaolong
Zhang Yanling
Wang Liangliang
Liu Wenjie
Su Wenshuo
Abstract：Objective To investigate the evaluation value of serum latent transforming growth factor β-binding protein-2(LT-BP-2)and paraoxonase-1(PON-1)levels on the condition and acute exacerbation in children with bronchial asthma,aiming to provide a reference for clinical treatment.Methods A total of 116 children with bronchial asthma admitted to First Hos-pital of Qinhuangdao from August 2020 to June 2024 were selected as research participants.Based on disease severity,they were assigned to a mild group(n=52),moderate group(n=38),and severe group(n=26).According to whether the children were in an acute attack phase,they were allocated to an acute group(n=71)and a remission group(n=45).Addi-tionally,100 healthy children undergoing physical examinations during the same period were selected as a healthy group.General data(e.g.,age,sex)and serum LTBP-2 and PON-1 levels were collected from all participants.Forced expiratory volume in one second(FEV1)and FEV1 as a percentage of predicted value were measured in children with bronchial asthma.Results LTBP-2 levels in the mild,moderate,and severe groups were significantly higher than those in the healthy group,while serum PON-1 levels were lower than those in the healthy group,with statistically significant differences(P＜0.05).As disease severity increased,LTBP-2 levels gradually rose,and PON-1 levels gradually declined,with statistically signifi-cant differences(P＜0.05).LTBP-2 levels in the acute group were higher than those in the remission group,while PON-1 levels,FEV1,and FEV1 as a percentage of predicted value were lower than those in the remission group,with statistically significant differences(P＜0.05).LTBP-2 levels in children with bronchial asthma were positively correlated with disease severity and negatively correlated with FEV1 and FEV1 as a percentage of predicted value(P＜0.001).PON-1 levels were negatively correlated with disease severity and positively correlated with FEV1 and FEV1 as a percentage of predicted value(P＜0.001).The areas under the curve(AUC)for serum LTBP-2,PON-1,and LTBP-2 plus PON-1 in evaluating acute exacerbation in children with bronchial asthma were 0.784(95％CI:0.739-0.834),0.837(95％CI:0.792-0.887),and 0.919(95％CI:0.874-0.969),respectively.Conclusion Serum LTBP-2 and PON-1 levels are significantly correla-ted with disease severity and lung function in children with bronchial asthma.Clinically,monitoring changes in these two in-dicators can help assess disease progression and acute attack risk.Moreover,the study shows that combined detection of both indicators has a higher evaluation value for acute exacerbation in children with bronchial asthma than single-indicator detection,providing a more reliable reference for clinical diagnosis and treatment.
Keywords：Latent transforming growth factor β-binding protein-2Paraoxonase-1Bronchial asthmaAcute exacerbation phase
Publication Date：2025-06-20
Online Publishing Date：2025-10-13(First online date of this platform, not the publication date of the document)
Pages：6( 58-63 )