Relationship of mean platelet volume,lymphocyte count and their ratio to post-cesarean deep vein thrombosis in preeclampsia patients

Song Zhining; Meng Yanxiao; Meng Xiulan; Liu Lili; Li Shasha; Cui Haonan; Liu Bing; Wang Di

doi:10.11986/j.issn.1673-873X.2025.06.08

Abstract：Objective To investigate the relationship between mean platelet volume(MPV),lymphocyte count(LYC)and their ratio,and the occurrence of deep vein thrombosis(DVT)after cesarean delivery in patients with preeclampsia(PE),thereby providing a reference for clinical management.Methods From February 2022 to October 2024,112 patients with PE who underwent cesarean section at Xingtai Central Hospital were enrolled.According to whether postoperative DVT oc-curred,patients were assigned to a DVT group(n=27)and a non-DVT group(n=85).Patients in the DVT group were further stratified by the Wells clinical score into mild(≤ 0 point,n=11),moderate(1-2 points,n=10)and high(≥ 3 points,n=6)subgroups.MPV and LYC were measured using an automated hematology analyzer,and the MPV/LYC ratio(MPVLR)was calculated.Receiver operating characteristic(ROC)curves were used to analyze the predictive value of MPV,LYC and MPVLR for post-cesarean DVT in PE patients.Multivariate logistic regression was adopted to identify fac-tors influencing postoperative DVT in PE patients.Results MPV and MPVLR were higher and LYC was lower in the DVT group than in the non-DVT group,with statistically significant differences(P＜0.05).Comparisons of MPV,LYC and MPVLR across Wells score subgroups showed significant differences in MPV,LYC,and MPVLR(P＜0.05):MPV and MPVLR increased and LYC decreased progressively from the mild to the moderate to the high-risk groups(P＜0.05).MPV and MPVLR were positively correlated with the Wells clinical score,while LYC was negatively correlated with the Wells clinical score(P＜0.05).The areas under the ROC curves(AUC)for MPV,LYC and MPVLR to predict post-cesar-ean DVT were 0.741(95％CI:0.696-0.791),0.863(95％CI:0.818-0.908)and 0.922(95％CI:0.872-0.967),re-spectively.Multivariate analysis showed that BMI ≥28.00 kg/m2 at delivery(OR=1.799;95％CI:1.182-2.736),base-line systolic blood pressure ≥140 mmHg(1 mmHg=0.133 kPa)(OR=1.640;95％CI:1.126-2.390),comorbid with varicose veins(OR=2.121;95％CI:1.302-3.456),MPV ≥10.85 fL(OR=2.545;95％CI:1.650-3.924),LYC ≤1.68×109/L(OR=2.392;95％CI:1.566-3.652),and MPVLR ≥ 6.46(OR=3.377;95％CI:1.947-5.858)were independent risk factors for post-cesarean DVT in these patients(P＜0.05).Conclusion MPV,LYC and their ratio are closely correlated with the occurrence of DVT after cesarean delivery in patients with PE and may serve as important predic-tive indicators,with the MPVLR showing superior predictive performance.