Clinical observation on the efficacy of Dachaihu decoction in treating acute pancreatitis

Xiao Xiong; Li Shu; Fan Tao; Li Rendong; Lu Xuelian; Wen Yun; Wang Yan

doi:10.11986/j.issn.1673-873X.2025.05.19

Abstract：Objective To investigate the clinical efficacy of Dachaihu decoction in treating acute pancreatitis(AP),aiming to pro-vide a reference for clinical treatment.Methods This study selected 60 AP patients treated at Chengdu Fifth People's Hospital from May 2021 to December 2022 as research participants.Patients were allocated to a control group and a study group using a random number table,with 30 patients in each group.The control group received somatostatin treatment;the study group received modified Dachaihu decoction in addition to the control group's treatment.Traditional Chinese Medicine(TCM)syn-drome scores,intestinal flora levels,serum inflammatory factors,and biochemical indicators were compared between the two groups before and after treatment.Results Before treatment,there were no statistically significant differences in TCM syn-drome scores for epigastric and abdominal distension and pain,sticky and obstructed stool,chest tightness,fever,excessive thirst with preference for drinking,and scanty dark-yellow urine between the two groups(P＞0.05).After treatment,TCM syndrome scores for all six symptoms decreased in both groups compared to before treatment,and the study group had lower scores than the control group,with statistically significant differences(P＜0.05).Before treatment,there were no statistically significant differences in the counts of Enterobacteriaceae,Enterococcus,Bifidobacterium,and Lactobacillus in intestinal flora between the two groups(P＞0.05).After treatment,counts of Enterobacteriaceae and Enterococcus decreased in both groups compared to before treatment,while counts of Bifidobacterium and Lactobacillus increased;moreover,the study group had fe-wer Enterobacteriaceae and Enterococcus and more Bifidobacterium and Lactobacillus than the control group,with statistically significant differences(P＜0.05).Before treatment,there were no statistically significant differences in serum interleukin-6(IL-6),procalcitonin(PCT),or tumor necrosis factor-α(TNF-α)levels between the two groups(P＞0.05).After treat-ment,IL-6,PCT,and TNF-α levels decreased significantly in both groups,and the study group had significantly lower levels than the control group(P＜0.05).Before treatment,there were no statistically significant differences in white blood cell(WBC)count,amylase(AMS),or lipase(LPS)levels between the two groups(P＞0.05).After treatment,WBC,AMS,and LPS levels decreased significantly in both groups compared to before treatment,and the study group had significantly lower levels than the control group(P＜0.05).Conclusion Dachaihu decoction demonstrates marked efficacy in treating AP,effec-tively promoting the restoration of intestinal microecology and digestive function while mitigating inflammatory responses,holding promise for clinical promotion and application.