Effects of Bailing capsule as adjunctive therapy on serum FGF23,Klotho levels,and bone mineral density in early diabetic kidney disease patients
Fu Caiwen
Yu Helin
Li Yuyan
Li Yuanmei
Huang Xiuli
Zhou Yanjun
Wu Yan
Abstract：Objective To investigate the clinical efficacy of Bailing capsule as adjunctive therapy for early diabetic kidney disease(EDKD)and its effects on serum fibroblast growth factor 23(FGF23),Klotho protein,and bone mineral density,providing references for clinical treatment.Methods Eighty type 2 diabetes mellitus(T2DM)patients from outpatient and inpatient set-tings at Suining Central Hospital(December 2022-September 2023)were allocated to control(n=40)and study(n=40)groups using a random number table.The control group received conventional treatment;the study group received additional o-ral Bailing capsule.Clinical efficacy and adverse reactions during treatment were compared.Glycated hemoglobin(HbA1c),parathyroid hormone(PTH),serum calcium(Ca),phosphorus(Pi),uric acid(UA),serum creatinine(SCr),blood urea ni-trogen(BUN),urinary albumin excretion rate(UAER),FGF23,Klotho levels,and average bone mineral density(avBMD)were measured before treatment and after 6 months.Results The overall response rate was significantly higher in the study group than in controls(P＜0.05).Adverse reaction rates showed no intergroup difference(P＞0.05).Pre-treatment fasting plasma glucose(FPG),HbA1c,UA,SCr,BUN,and UAER showed no significant intergroup differences(P＞0.05);post-treatment HbA1c,UA,SCr,BUN,and UAER were significantly lower in the study group versus controls(P＜0.05),but FPG showed no significant intergroup difference(P＞0.05).In the control group,post-treatment FPG,HbA1c,BUN,and UAER decreased significantly as compared with pre-treatment(P＜0.05),while UA and SCr showed no significant changes(P＞0.05).In the study group,FPG,HbA1c,UA,SCr,BUN,and UAER all decreased significantly versus pre-treatment(P＜0.05).Pre-treatment PTH,Ca,Pi,avBMD,FGF23,and Klotho showed no significant intergroup differences(P＞0.05).Post-treatment avBMD and Klotho in the study group were significantly higher,while FGF23 was significantly lower than in the control group(P＜0.05),but PTH,Ca,and Pi showed no significant intergroup differences(P＞0.05).In con-trols,post-treatment PTH decreased significantly versus pre-treatment(P＜0.05),while Ca,Pi,avBMD,FGF23,and Klotho showed no significant changes(P＞0.05).In the study group,post-treatment PTH and FGF23 decreased,while avB-MD and Klotho increased significantly compared with pre-treatment(P＜0.05).Conclusion Bailing capsule adjunctive con-ventional therapy improves renal function,promotes overall efficacy,and delays disease progression in EDKD.The FGF23/Klotho endocrine axis may serve as an early biomarker for predicting calcium-phosphorus mineral metabolism disorders and re-duced bone density.
Keywords：Early diabetic kidney diseaseType 2 diabetesBailing capsuleBone mineral density
Publication Date：2025-05-20
Online Publishing Date：2025-09-04(First online date of this platform, not the publication date of the document)
Pages：6( 109-114 )