Predictive value of(neutrophils+monocytes)/lymphocytes ratio for major adverse cardiovascular events in coronary heart disease patients combined with heart failure
Zong Lihong
Zhu Xiangling
Wang Chen
Ding Xinjie
Sun Wenqian
Guan Aili
Lyu Wei
Shi Xuekun
Abstract：Objective To investigate the predictive value of(neutrophils+monocytes)/lymphocytes ratio(NMLR)for major adverse cardiovascular events(MACE)in coronary heart disease(CHD)patients combined with heart failure,providing refer-ences for clinical decision-making.Methods A total of 104 CHD patients combined with heart failure admitted to a hospital in Shandong Province from December 2022 to December 2023 were enrolled.Baseline/clinical data and admission NMLR were collected.Based on the 1-year follow-up MACE occurrence,patients were allocated to the MACE and non-MACE groups.Re-ceiver operating characteristic(ROC)curves were plotted to analyze NMLR's predictive value for MACE;multivariate logistic regression was adopted to identify MACE risk factors.Results NMLR was significantly higher in the MACE group(6.57±1.39)than in the non-MACE group(3.12±0.78;t=16.238,P<0.001).The area under the curve(AUC)(95%CI)of NMLR for predicting MACE among CHD patients combined with heart failure was 0.916(0.871-0.966),with a sensitivity of 86.91%and a specificity of 85.13%at a cutoff of 5.15.Univariate analysis showed no significant differences in body mass index,gender distribution,heart rate,systolic/diastolic blood pressure,left ventricular ejection fraction,NYHA or Killip functional classification,percutaneous coronary intervention history,history of smoking,history of alcohol consumption,or comorbidities(hypertension/diabetes/hyperlipidemia)between groups(P>0.05).Age,creatinine,and uric acid levels were significantly higher in the MACE group than in the non-MACE group(P<0.05).Multivariate stepwise logistic regression i-dentified age(OR=2.252,95%CI:1.278-3.969)and NMLR(OR=3.684,95%CI:1.870-7.258)as influencing fac-tors of MACE among CHD patients combined with heart failure(P<0.05).Conclusion Elevated NMLR is a predictive factor of MACE in CHD patients combined with heart failure and may identify high-risk populations.
Keywords：Coronary heart diseaseHeart failureMajor adverse cardiovascular events(Neutrophils+monocytes)/lympho-cytesPredictive value
Publication Date：2025-04-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 108-113 )