Efficacy observation of betahistine combined with flunarizine and vertigo therapeutic apparatus for benign paroxysmal positional vertigo

Li Bo; Tong Yangping; Yun Zongjin; Xiao Gairong; Yang Junying; Zhang Qun; Song Bin

doi:10.11986/j.issn.1673-873X.2025.04.09

Abstract：Objective To investigate the efficacy of betahistine combined with flunarizine and vertigo therapeutic apparatus for benign paroxysmal positional vertigo(BPPV),providing references for clinical treatment.Methods A total of 106 BPPV pa-tients admitted to Fuyang Hospital Affiliated to Anhui Medical University from October 2021 to January 2024 were enrolled.Patients were assigned to two groups(n=53 each)using a random number table.The control group received betahistine com-bined with flunarizine.The study group received additional vertigo therapeutic apparatus.Dizziness Handicap Inventory(DHI)and Vertigo Symptom Scale(VSI)scores were compared before treatment and at 1 and 3 weeks of treatment.Clinical efficacy and prognosis were compared between groups.Results Before treatment,no significant difference was noted in DHI scores between groups(P>0.05);at 1 and 3 weeks of treatment,DHI scores decreased significantly in both groups compared to pre-treatment levels,with the study group significantly lower than the control group(P<0.05).Before treatment,no significant difference was observed in VSI scores between groups(P>0.05);at 1 and 3 weeks of treatment,VSI scores decreased signifi-cantly in both groups compared to pre-treatment levels,with the study group significantly lower than the control group(P<0.05).The overall response rate was significantly higher in the study group than in the control group(P<0.05).No signifi-cant difference was found in adverse reaction rates between groups(P>0.05).The recurrence rate was significantly lower in the study group than in the control group(P<0.05).Conclusion The combined approach(betahistine combined with flunari-zine and vertigo therapeutic apparatus)achieves precise repositioning through the apparatus while restoring inner ear balance function pharmacologically,demonstrating superior overall efficacy and prognosis.This provides a comprehensive and effective treatment regimen for BPPV patients.