Expression of shear wave elastography combined with contrast-enhanced ultrasound parameters in diagnosing benign and malignant thyroid nodules
Deng Wanyue
Zhu Chen
Jiang Ping
Wu Hao
Cao Wenbin
Wang Lei
Cheng Weiran
Wen Qiao
Abstract：Objective To evaluate the diagnostic value of shear wave elastography(SWE)combined with contrast-enhanced ultrasound(CEUS)parameters in differentiating benign and malignant thyroid nodules,providing references for clinical management.Methods A total of 120 thyroid nodule patients admitted to Ziyang Central Hospital and Sichuan Provincial People's Hospital from January to October 2024 were enrolled.Based on pathological diagnosis,patients were divided into benign(n=69)and malignant(n=51)groups.All patients underwent SWE and CEUS examinations.Quantitative SWE parameters[maximum elasticity(Emax),minimum elasticity(Emin),mean elasticity(Emean)]and CEUS parameters[time to peak(TIP),peak intensity(PI),area under the time-intensity curve(AUC)]were compared between groups.Re-ceiver operating characteristic(ROC)curve analysis assessed the diagnostic efficacy of combined SWE and CEUS parame-ters.Results The combined SWE and CEUS approach demonstrated substantial diagnostic agreement(Kappa=0.881)for thyroid nodule characterization,with sensitivity of 94.12%(48/51),specificity of 94.20%(65/69),accuracy of 94.17%(113/120),positive predictive value of 92.31%(48/52),and negative predictive value of 95.58%(65/68).The malignant group exhibited significantly higher Emax,Emin,Emean,and TIP values than the benign group(P<0.05),while PI and AUC were significantly lower in the malignant group than the benign group(P<0.05).ROC analysis revealed an AUC of 0.973 for the combined parameters,with a sensitivity of 0.92 and specificity of 0.94.Conclusion Quantitative parameters from combined SWE and CEUS demonstrate high diagnostic efficacy for differentiating thyroid nodules,providing new in-sights for clinical diagnosis.
Keywords：Thyroid noduleBenign and malignantShear wave elastographyContrast-enhanced ultrasoundQuantitative parameters
Publication Date：2025-03-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 119-124 )