Predictive value of mean platelet volume-to-lymphocyte ratio for postoperative deep vein thrombosis in patients with lower limb traumatic fractures
Zhang Lipeng
Qu Fufeng
Zhai Yingjie
Zhao Xudong
Zhou Xinli
Wang Dong
Zhang Lei
Li Xue
Zhao Xiaolong
Abstract：Objective To investigate the predictive value of mean platelet volume-to-lymphocyte ratio(MPVLR)for postop-erative deep vein thrombosis(DVT)in patients with lower limb traumatic fractures,providing evidence for targeted preven-tive interventions.Methods A total of 132 patients with lower limb traumatic fractures admitted to Hanzhong Central Hos-pital from January 2019 to July 2024 were enrolled.Postoperative mean platelet volume(MPV)and lymphocyte(LYM)levels were measured,and MPVLR was calculated.Patients were allocated to DVT(n=38)and non-DVT(n=94)groups based on postoperative DVT occurrence.The predictive value of MPV,LYM,and MPVLR for DVT was analyzed,and risk factors for postoperative DVT were explored.Results The DVT group exhibited significantly higher MPV and MPVLR but lower LYM compared to the non-DVT group(P<0.05).Receiver operating characteristic(ROC)analysis showed that MPV,LYM,and MPVLR predicted postoperative DVT with AUCs of 0.739(95%CI:0.694-0.789),0.802(95%CI:0.752-0.847),and 0.913(95%CI:0.868-0.963),respectively,with an optimal MPVLR cutoff of 7.82.No signifi-cant differences existed in age,sex,body mass index(BMI),fracture type,injury site,surgical approach,or alcohol histo-ry(P>0.05).However,the DVT group had longer operative duration,prolonged postoperative bed rest,and higher rates of smoking history,hypertension,and diabetes(P<0.05).Binary logistic regression identified prolonged operative time(OR=2.312,95%CI:1.315-4.065),extended bed rest(OR=2.686,95%CI:1.345-5.365),MPV≥10.65 fL(OR=2.680,95%CI:1.440-4.989),LYM≤1.60×109/L(OR=2.898,95%CI:1.629-5.156),and MPVLR≥7.82(OR=4.208,95%CI:2.174-8.146)as independent risk factors(P<0.05).Conclusion MPVLR demonstrates significant value in predicting DVT risk after lower limb fracture surgery,providing a reliable biomarker for early clinical intervention.
Keywords：Lower limb traumatic fracturesDeep vein thrombosisMean platelet volumeLymphocyteMean platelet vol-ume-to-lymphocyte ratioPredictive valueInfluencing factors
Publication Date：2025-03-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 68-74 )