Expression of SOS1 and FRS2 in breast invasive ductal carcinoma tissues and their relationship with clinicopathological characteristics
Li Yang
Li Qisong
Ding Congling
Wang Qing
Zhou Huihui
Wang Manqiu
Yang Jie
Abstract：Objective To investigate the expression of Son of Sevenless Homolog 1(SOS1)and Fibroblast Growth Factor Receptor Substrate 2(FRS2)in breast invasive ductal carcinoma(IDC)tissues and their correlation with clinicopathological characteristics,providing insights for clinical management.Methods A total of 110 IDC patients admitted to Xuancheng Central Hospital from January 2017 to December 2023 were enrolled.Carcinoma tissues and adjacent normal tissues obtained surgically were designated as the IDC group and control group,respectively.The expression of SOS1 and FRS2 in IDC tis-sues and their associations with clinicopathological characteristics were analyzed.Univariate and multivariate logistic regres-sion identified factors influencing axillary lymph node metastasis(ALNM).Results The IDC group exhibited significantly higher positive expression rates of SOS1 and FRS2 compared to the control group(P<0.05).IDC tissues with advanced clinical stages(Ⅲ-Ⅳ),poor differentiation,or lymphovascular invasion showed significantly higher positive expression rates of SOS1 and FRS2 than those with early stages(Ⅰ-Ⅱ),moderate/high differentiation,or no lymphovascular inva-sion(P<0.05).Multivariate analysis identified poor differentiation,lymphovascular invasion,SOS1 positive expression,and FRS2 positive expression as independent risk factors for ALNM(P<0.05).Conclusion SOS1 and FRS2 were mainly positively expressed in IDC tissues,with expression levels correlating with clinical stage,differentiation grade,and lympho-vascular invasion.Both serve as influence factors for ALNM.
Keywords：SOS1FRS2Breast invasive ductal carcinomaPathological characteristicsAxillary lymph node metastasis
Publication Date：2025-03-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 41-46 )