Analysis of risk factors and serological indicators for hypertensive intracerebral hemorrhage in middle-aged and young adults in the Ankang region
Wang Kai
Fan Xiaoxuan
Tang Yong
Chen Liang
Wang Xiaoling
Chen Xiangrong
Abstract：Objective This study aimed to analyze the risk factors for hypertensive intracerebral hemorrhage(HICH)and differ-ences in serological indicators between HICH and hypertension patients in middle-aged and young adults in the Ankang region,providing reference for disease prevention and treatment.Methods A total of 1 286 patients who admitted to Ankang Tradi-tional Chinese Hospital from July 2021 to December 2023 were enrolled in the study,including 245 HICH patients and 1 041 hypertension patients.Clinical data and laboratory results were collected for univariate and multivariate logistic regression ana-lyses of HICH risk factors.Results HICH patients had a significantly higher proportion of patients with grade 2 or 3 hyper-tension,obesity,smoking history,physical inactivity,stroke-prone TCM constitutions,a history of diabetes,a history of dys-lipidemia,sleep disorders,family history of cardiovascular disease,and abnormal marital status(P＜0.05).Serological analy-sis showed that HICH patients had significantly higher levels of fasting blood glucose,cystatin C,low-density lipoprotein cho-lesterol,apolipoprotein B,and homocysteine(P＜0.05).Multivariate logistic regression identified high hypertension grade(OR=2.351),obesity(OR=1.689),smoking history(OR=1.584),physical inactivity(OR=1.515),stroke-prone TCM con-stitution(OR=1.738),a history of diabetes(OR=2.121),a history of dyslipidemia(OR=2.001),sleep disorders(OR=1.736),family history of cardiovascular disease(OR=1.606),abnormal marital status(OR=1.649),elevated fasting blood glucose(OR=1.075),elevated cystatin C(OR=1.723),elevated low-density lipoprotein cholesterol(OR=1.156),and ele-vated homocysteine(OR=1.026)as risk factors for HIGH(P＜0.05).Conclusion HICH in middle-aged and young adults in Ankang is linked to hypertension grade,obesity,smoking,inactivity,stroke-prone TCM constitutions,diabetes,dyslipi-demia,sleep disorders,family history of cardiovascular disease,abnormal marital status,and elevated fasting blood glucose,cystatin C,low-density lipoprotein cholesterol,and homocysteine.Early preventive measures should be taken clinically for in-dividuals with these risk factors.
Keywords：Middle-aged and young adultsHypertensive intracerebral hemorrhageRisk factorsSerological indicators
Publication Date：2025-02-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 94-100 )